Literature Review of Subcortical Mapping Techniques in Glioblastoma Surgeries

Authors

  • Mehak Satsangi School of Behavioral & Brain Sciences, The University of Texas at Dallas, Richardson, Texas, USA; Global Innervation LLC, Dallas, Texas, USA https://orcid.org/0009-0007-8165-600X
  • Carolyn Iduh School of Behavioral & Brain Sciences, The University of Texas at Dallas, Richardson, Texas, USA; Global Innervation LLC, Dallas, Texas, USA https://orcid.org/0009-0006-4020-0973
  • Faisal R Jahangiri School of Behavioral & Brain Sciences, The University of Texas at Dallas, Richardson, Texas, USA; Global Innervation LLC, Dallas, Texas, USA https://orcid.org/0000-0002-1342-1977

DOI:

https://doi.org/10.5281/zenodo.14420746

Keywords:

Subcortical mapping, glioblastoma, SSEP, MEP, tcMEP, motor mapping, EEG, ECoG, somatosensory evoked potentials, EMG, electromyography, electroencephalography, phase reversal, TOF, Penfield, Taniguchi

Abstract

Subcortical mapping of glioblastoma is an intraoperative technique used during tumor resection to identify the motor and language pathways in the central nervous system of the brain that are possibly affected by glioblastoma, an aggressive type of brain tumor that develops from glial cells with poor prognosis.  This technique involves using electrical probes in varying brain tissues in an awake patient to stimulate different brain regions and critical areas responsible for language and movement. Combining intraoperative modalities like somatosensory evoked potential (SSEP), direct electrical stimulation (DES), electromyography (EMG), and electrocorticography (ECoG), Electroencephalography (EEG), Train of four (TOF) and Phase reversal, the surgical team can monitor neural activity.  Penfield and Taniguchi have developed two methods to map the corticospinal tracts intraoperatively. One of these approaches may be used depending on the tumor's location, the patient's medical history, the surgery, and other considerations. Like other intraoperative monitoring techniques, the use of subcortical mapping during tumor resection in glioblastoma helps surgeons minimize the risk of postoperative deficits with the possibility of improving surgical outcomes for patients with this disease.

References

Ostrom, Q. T., L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, et al. 2014. “The Epidemiology of Glioma in Adults: A ‘State of the Science’ Review.” Neuro-Oncology 16 (7): 896–913. https://doi.org/10.1093/neuonc/nou087.

Greisman, Jacob D., Nicholas B. Dadario, Jung Park, Justin W. Silverstein, and Randy S. D’Amico. 2022. “Subcortical Stimulation in Brain Tumor Surgery: A Closer Look beneath the Surface.” World Neurosurgery 161 (May): 55–63. https://doi.org/10.1016/j.wneu.2022.02.014.

Raabe, Andreas, Jürgen Beck, Philippe Schucht, and Kathleen Seidel. 2014. “Continuous Dynamic Mapping of the Corticospinal Tract during Surgery of Motor Eloquent Brain Tumors: Evaluation of a New Method.” Journal of Neurosurgery 120 (5): 1015–24. https://doi.org/10.3171/2014.1.jns13909.

Han, Seunggu Jude, Irene Troncon, Ramin Morshed, Kesshi Jordan, Roland Henry, and Mitchel S Berger. 2017. “SURG-03. SUBCORTICAL STIMULATION MAPPING of DESCENDING MOTOR PATHWAYS for PERIROLANDIC GLIOMAS: ASSESSMENT of MORBIDITY and FUNCTIONAL OUTCOME in over 700 PATIENTS.” Neuro-Oncology 19 (suppl_6): vi235–36. https://doi.org/10.1093/neuonc/nox168.960.

Porčnik, Andrej, Metka Novak, Barbara Breznik, Bernarda Majc, Barbara Hrastar, Neja Šamec, Alja Zottel, et al. 2021. “TRIM28 Selective Nanobody Reduces Glioblastoma Stem Cell Invasion.” Molecules 26 (17): 5141. https://doi.org/10.3390/molecules26175141.

Jahangiri, Faisal R, Aksharkumar Dobariya, Aaron Kruse, Olga Kalyta, and John D Moorman. n.d. “Mapping of the Motor Cortex.” Cureus 12 (9): e10645. https://doi.org/10.7759/cureus.10645.

Jahangiri F R, Pautler K, Watters K, et al. (March 19, 2020) Mapping of the Somatosensory Cortex. Cureus 12(3): e7332. doi:10.7759/cureus.7332.

Jahangiri F R, Liang M, Kabir S S, et al. (May 11, 2022) Motor Mapping of the Brain: Taniguchi Versus Penfield Method. Cureus 14(5): e24901. doi:10.7759/cureus.24901

Jahangiri F R, Jahangiri R H, Asad H, et al. (October 05, 2022) Scoliosis Corrective Surgery With Continuous Intraoperative Neurophysiological Monitoring (IONM). Cureus 14(10): e29958. doi:10.7759/cureus.29958

Tarapore, Phiroz E., Anne M. Findlay, Susanne M. Honma, Danielle Mizuiri, John F. Houde, Mitchel S. Berger, and Srikantan S. Nagarajan. 2013. “Language Mapping with Navigated Repetitive TMS: Proof of Technique and Validation.” NeuroImage 82 (November): 260–72. https://doi.org/10.1016/j.neuroimage.2013.05.018.

Han, Seunggu J., Ramin A. Morshed, Irene Troncon, Kesshi M. Jordan, Roland G. Henry, Shawn L. Hervey-Jumper, and Mitchel S. Berger. 2018. “Subcortical Stimulation Mapping of Descending Motor Pathways for Perirolandic Gliomas: Assessment of Morbidity and Functional Outcome in 702 Cases.” Journal of Neurosurgery 131 (1): 2018. https://doi.org/10.3171/2018.3.JNS172494.

Saito, Taiichi, Yoshihiro Muragaki, Manabu Tamura, Takashi Maruyama, Masayuki Nitta, Shunsuke Tsuzuki, Mana Ohashi, Atsushi Fukui, and Takakazu Kawamata. 2021. “Awake Craniotomy with Transcortical Motor Evoked Potential Monitoring for Resection of Gliomas within or close to Motor-Related Areas: Validation of Utility for Predicting Motor Function.” Journal of Neurosurgery 136 (4): 1052–61. https://doi.org/10.3171/2021.3.JNS21374.

Bello, Lorenzo, Marco A Riva, Enrica Fava, Valentina Ferpozzi, Antonella Castellano, Fabio Raneri, Federico Pessina, Alberto Bizzi, Andrea Falini, and Gabriella Cerri. 2014. “Tailoring Neurophysiological Strategies with Clinical Context Enhances Resection and Safety and Expands Indications in Gliomas Involving Motor Pathways.” Neuro-Oncology 16 (8): 1110–28 https://doi.org/10.1093/neuonc/not327.

Kim, Keewon, Charles Cho, Moon-suk Bang, Hyung-ik Shin, Ji-Hoon Phi, and Seung-Ki Kim. 2018. “Intraoperative Neurophysiological Monitoring: A Review of Techniques Used for Brain Tumor Surgery in Children.” Journal of Korean Neurosurgical Society 61 (3): 363–75. https://doi.org/10.3340/jkns.2018.0078.

Krieg, S.M., Lioumis, P., Mäkelä, J.P. et al. Protocol for motor and language mapping by navigated TMS in patients and healthy volunteers; workshop report. Acta Neurochir 159, 1187–1195 (2017). https://doi.org/10.1007/s00701-017-3187-z.

Saito, Taiichi, Yoshihiro Muragaki, Manabu Krieg, S.M., Lioumis, P., Mäkelä, J.P. et al. Protocol for motor and language mapping by navigated TMS in patients and healthy volunteers; workshop report. Acta Neurochir 159, 1187–1195 (2017). https://doi.org/10.1007/s00701-017-3187-z.

Tamura, Takashi Maruyama, Masayuki Nitta, Shunsuke Tsuzuki, Mana Ohashi, Atsushi Fukui, and Takakazu Kawamata. 2022. “Awake Craniotomy with Transcortical Motor Evoked Potential Monitoring for Resection of Gliomas within or close to Motor-Related Areas: Validation of Utility for Predicting Motor Function.” Journal of Neurosurgery 136 (4): 1052–61. https://doi.org/10.3171/2021.3.JNS21374.

Stark, Andreas M., Julia van de Bergh, Jürgen Hedderich, H. Maximilian Mehdorn, and Arya Nabavi. 2012. “Glioblastoma: Clinical Characteristics, Prognostic Factors and Survival in 492 Patients.” Clinical Neurology and Neurosurgery 114 (7): 840–45. https://doi.org/10.1016/j.clineuro.2012.01.026.

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Published

2025-01-11

How to Cite

Satsangi, M., Iduh, C., & Jahangiri, F. R. (2025). Literature Review of Subcortical Mapping Techniques in Glioblastoma Surgeries. J of Neurophysiological Monitoring, 3(1), 8–27. https://doi.org/10.5281/zenodo.14420746

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Vol. 3 No. 1 (2025): Journal of Neurophysiological Monitoring

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