Stroke Incidence in Cerebral Aspergillosis: A meta-analysis
DOI:
https://doi.org/10.5281/zenodo.10324425Keywords:
Meta-analysis, cerebral aspergillosis, stroke, aspergillus fumigatus, subarachnoid hemorrhage, immunocompromisedAbstract
Cerebral aspergillosis is an opportunistic disease most commonly caused by the fungus Aspergillus fumigatus. Invasive infection with Aspergillus has been reported due to the extension of infection usually affecting immune-compromised individuals. The fungus may cause direct artery invasion or mycotic aneurysm, causing intracerebral or subarachnoid hemorrhage. The study compiled data from 27 studies with a combined sample size of 82 individuals. The results showed that these patients had a high risk of stroke. The risk was higher in immunocompromised patients with lung or kidney transplantation and debilitated patients who have alcoholism, diabetes mellitus, liver failure, renal failure, drug addiction, leukemia, or malignant lymphoma. Radiographic studies of these patients showed narrowed cerebral vessels. This meta-analysis investigates the incidence rate of stroke in patients with cerebral aspergillosis, its presenting signs, and a review of risk factors and complications of aspergillosis. Advanced diagnostic and treatment approaches to cerebral aspergillosis and future research directions are discussed.
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